Computer Science
Scientific paper
Dec 2011
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2011oleb...41..621f&link_type=abstract
Origins of Life and Evolution of Biospheres, Volume 41, Issue 6, pp.621-632
Computer Science
Aminoacyl-Trna Synthetase, Paralog, Genetic Code, Luca, Horizontal Gene Transfer
Scientific paper
Aminoacyl-tRNA synthetases (aaRS) consist of several families of functionally conserved proteins essential for translation and protein synthesis. Like nearly all components of the translation machinery, most aaRS families are universally distributed across cellular life, being inherited from the time of the Last Universal Common Ancestor (LUCA). However, unlike the rest of the translation machinery, aaRS have undergone numerous ancient horizontal gene transfers, with several independent events detected between domains, and some possibly involving lineages diverging before the time of LUCA. These transfers reveal the complexity of molecular evolution at this early time, and the chimeric nature of genomes within cells that gave rise to the major domains. Additionally, given the role of these protein families in defining the amino acids used for protein synthesis, sequence reconstruction of their pre-LUCA ancestors can reveal the evolutionary processes at work in the origin of the genetic code. In particular, sequence reconstructions of the paralog ancestors of isoleucyl- and valyl- RS provide strong empirical evidence that at least for this divergence, the genetic code did not co-evolve with the aaRSs; rather, both amino acids were already part of the genetic code before their cognate aaRSs diverged from their common ancestor. The implications of this observation for the early evolution of RNA-directed protein biosynthesis are discussed.
Alm Eric J.
Andam Cheryl P.
Fournier Gregory P.
Gogarten Peter J.
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