Mechanism of Calcification in Mammalian Bone

Details Mechanism of Calcification in Mammalian Bone Mechanism of Calcification in Mammalian Bone

Dec 1966

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1966natur.212.1250d&link_type=abstract

Nature, Volume 212, Issue 5067, pp. 1250-1252 (1966).

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Scientific paper

WHEN supplies of calcium, phosphorus and various other humoral factors are adequate, calcification of mammalian bone is usually attributed to the local action of enzymes and to a template mechanism. These theories are not wholly satisfactory, because the enzymes are also found at sites where calcification does not occur and a variety of substances besides collagen of the appropriate molecular spacing can act as nucleating agents for the deposition of bone salts1,2. An electrochemical mechanism may be involved in remoulding, for bone forms round the cathode of a small mercury cell implanted into a living dog femur3 and potentials are produced by piezo-electric effects resulting from stress in a formed bone4,5. Such a mechanism does not, however, readily account for the initiation of calcification.

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