RIBAVIRIN: The analysis of a polymorphic substance by LC-MS and FTIR spectroscopy

Details RIBAVIRIN: The analysis of a polymorphic substance by LC-MS and FTIR spectroscopy RIBAVIRIN: The analysis of a polymorphic substance by LC-MS and FTIR spectroscopy

Jun 1998

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1998aipc..430..453m&link_type=abstract

The eleventh international conference on fourier transform spectroscopy. AIP Conference Proceedings, Volume 430, pp. 453-456 (1

Other

Organic Compounds, Polymers, Infrared Spectrometers, Auxiliary Equipment, And Techniques

Scientific paper

The FTIR laboratory often has the task of identifying unknown pharmaceuticals. This case involves unknown capsules received at the Forensic Chemistry Center. Through extensive searching of pharmaceutical data bases, it was concluded that the capsules might contain ribavirin, which is classified as an anti-viral agent. Mass spectral analysis (LC-MS) concluded that the capsules contained ribavirin; however, the FTIR results did not agree with the mass spectral results. Additional experiments were performed and the results demonstrate the capabilities of FTIR to discern differences between polymorphic forms of a substance, such as ribavirin, when other techniques are unable to provide this information.

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