Biology – Quantitative Biology – Cell Behavior
Scientific paper
2010-12-10
Biology
Quantitative Biology
Cell Behavior
20 pages, 6 figures, to appear in J. Theor. Biol
Scientific paper
10.1016/j.jtbi.2010.12.010
A model is proposed to study the process of hypoxia-induced angiogenesis in cancer cells. The model accounts for the role played by the vascular endothelial growth factor (VEGF)-A in regulating the oxygen intake. VEGF-A is dynamically controlled by the HIF-1alpha concentration. If not degraded, HIF-1alpha can bind to the subunit termed HIF-1beta and so experience translocation to the nucleus, to exert its proper transcriptional activity. The delicate balance between these opposing tendencies translates into the emergence of distinct macroscopic behaviors in terms of the associated molecular concentrations that we here trace back to normoxia, hypoxia and death regimes. These aspects are firstly analyzed with reference to the ideal mean-field scenario. Stochastic fluctuations are also briefly discussed and shown to seed a cooperative interaction among cellular units, competing for the same oxygen reservoir.
Arcangeli Annarosa
Fanelli Duccio
Laise Pasquale
Masselli Marika
Patti Francesca Di
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